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Journal Of Pharmacy And Pharmacological Research Vol. 3.(1) pp. 22 - 26 August 2013
Available online http://www.globalresearchjournals.org/journal/jppr
Copyright ©2013 Global Research Journals
Full Length Research.
Arthogalin inhibits the growth of murine malignant prostate sarcoma cells in vitro.
Moombo C. Magaya, Dohole P. Yeang, and Bocary G. W. Ahkeboyee
Ocolinwar Center for Health, Asmara, Eritrea
Email: kuumwa@afra-mail.com
| Abstract |
We test the effects of Arthogalin, secondary metabolite of the lichen Caloplaca inclinans, on the growth of murine malignant prostate sarcoma cells in vitro. We find that Arthogalin is a potent inhibitor of growth. We also find that Arthogalin increases sensitivity of cells to radiation, and this effect is significant at a radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, Arthogalin shows promise for combined-modality cancer treatment.
Index Terms—lichen, secondary metabolite, cancer